Characterization of Pregelatinized, Pentanol and Acetylated Modified Primary Starch

Authors

  • Desy Nawangsari Universitas Harapan Bangsa
  • Rani Prabandari Universitas Harapan Bangsa
  • Dina Febrina Universitas Harapan Bangsa

DOI:

https://doi.org/10.35960/vm.v17i1.1354

Keywords:

characterization, starch modification., pratama taro

Abstract

Tablets are pharmaceutical preparations consisting of active ingredients and excipients. One of the commonly used excipients is starch. (Colocasia esculenta (L). Schott var, Pratama) is a plant that contains a high source of starch. The use of natural starch in tablets has limitations in the form of less fast flow and poor compressibility. The purpose of this study was to modify natural starch by pregelatinization, pentanol and acetylation. This research was conducted using laboratory experimental methods, starting with sorting the starch tubers of (Colocasia esculenta (L). Schott var, Pratama), starch isolation, modification and characterization of the resulting starch. The characterization results showed that the flow rate of natural starch, pregelatinized, pentanol and acetylated sequentially was 1.9 ± 0.19; 2.15 ± 0.37; 1.35 ± 0.15; and 1.95 ± 0.14 g/s with an angle of repose of 20.49 ± 1.99; 17.12 ± 1.99; 22.92 ± 1.18 and 20.06 ± 1.97°, while the compressibility value is 20.23 ± 5.31; 15.47 ± 3.03; 21, 09 ± 2.8 and 19.09 ± 2.05%.

References

Apriyanto, B. H., Rusli, R., & Rahmadani, A. (2017). Evaluasi Pati Umbi Talas (Colocasia esculenta Schott) Sebagai Bahan Pengisi Pada Sediaan Tablet Parasetamol. Proceeding of the 5th Mulawarman Pharmaceuticals Conferences, April, 23–24. https://doi.org/10.25026/mpc.v5i1.222

Astuti, Y., Nawangsari, D., & Prabandari, R. (2023). Karakterisasi Fisik Pati Kentang (Solanum Tuberosum L.) dengan Modifikasi Pentanol-1 dan Asetilasi. Seminar Nasional Penelitian Dan Pengabdian Kepada Masyarakat, 3(1), 473-480. https://doi.org/https://doi.org/10.35960/snppkm.v3i1.1244

Aulton, M. E., & Taylor, K. M. G. (2018). Aulton’s Pharmaceutics The Design and Manufacture of Medicines. In Aulton’s Pharmaceutics The Design and Manufacture of Medicines (5th ed). Elsevier.

Azhary, D. P., Zisca, R., Mardhiani, Y. D., & Utami, D. D. (2019). Modifikasi Amilum Ganyong (Canna indica L.) dengan Metode Pregelatinasi Parsial untuk Eksipien Tablet Kempa Langsung. PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 16(2), 256. https://doi.org/10.30595/pharmacy.v16i2.5450

Badwan, A. A., Rashid, I., Al Omari, M. M. H., & Darras, F. H. (2015). Chitin and chitosan as direct compression excipients in pharmaceutical applications. Marine Drugs, 13(3), 1519–1547. https://doi.org/10.3390/md13031519

Dadang Mulya Santosa, F. D. P. (2020). Formulasi Dan Uji Disolusi Terbanding Tablet Lepas Lambat Natrium Diklofenak Menggunakan Methocel K100M Sebagai Matriks. Indonesia Natural Research Pharmaceutical Journal, 5(2), 1–11. https://doi.org/10.52447/inspj.v5i2.181

Irhami, Anwar, C., & Kemalawaty, M. (2019). Karakteristik Sifat Fisikokimia Pati Ubi Jalar Dengan Mengkaji Jenis Varietas Dan Suhu Pengeringan. Jurnal Teknologi Pertanian, 20(1), 33–44.

Hartesi, B., Meirista, I., Mariska, R. P., Soyata, A., Fitria, F., & Lestari, O. (2023). Modifikasi Pati Beras Ketan Putih Sebagai Pengisi Pada Pembuatan Tablet Kempa Langsung. Majalah Farmasetika, 8(1), 70. https://doi.org/ 10.24198/mfarmasetika.v8i1.42081.

Hartesi, B., Meirista, I., Soyata, A., Mesra, N. D., & Saputri, C. D. (2022). Modifikasi Pati Ubi Jalar Merah (ipomoea batatas l.) Secara Pregelatinisasi dengan Perbandingan Pati dan Air (1:1,25) dan (1:1). Riset Informasi Kesehatan, 11(1), 82–93. https://doi.org/10.30644/rik.v11i1.600

Hartesi, B., Andriani, L., Anggresani, L., Whinata, M. B., & Haflin, H. (2020). Modifikasi pati kentang secara pregelatinasi dengan perbandingan pati dan air (1: 1,25). Riset Informasi Kesehatan, 9(2), 177. https://doi.org/10.30644/ rik.v9i2.431

Karmakar, R., Ban, D. K., & Ghosh, U. (2014). Comparative Study Of Native And Modified Starches Isolated From Conventional And Nonconventional Sources. International Food Research Journal, 21(2), 597–602.

Kemenperin. (2021). Membangun Kemandirian Industri Farmasi Nasional. In Kemenperin. https://www.kemenperin.go.id/download/26388/Buku-Analisis-Industri-Farmasi-2021

Kurniadi, A., Nawangsari, D., Samodra, G., & Prabandari, R. (2023). Profil Disolusi Tablet Lepas Lambat Kalium Diklofenak Menggunakan Pati Talas Pratama Sebagai Matriks. Jurnal Mandala Pharmacon Indonesia, 9(2), 562–573. https://doi.org/10.35311/jmpi.v9i2.358

Mahalia, L. D. (2018). Upaya Peningkatan Sifat Farmasetika Eksipien Sediaan Tablet dari Pati Ubi Jalar. Jurnal Surya Medika, 3(2), 106–114. https://doi.org/10.33084/jsm.v3i2.107

Mahalia, L. D., Supriyanto, S., & Syukri, Y. (2020). Development of sweet potato (ipomoea batatas lamk.) as excipient in tablet formulation. Journal of Public Health Research, 9(2), 161–164. https://doi.org/10.4081/jphr.2020.1831

Nawangsari, D. (2019). Pengaruh Bahan Pengisi Terhadap Massa Cetak Tablet Vitamin C. Viva Medika: Jurnal Kesehatan, Kebidanan Dan Keperawatan, 11(02), 37–42. https://doi.org/10.35960/vm.v11i02.464

Nurhayati, N. (2019). Modifikasi Pati Secara Asetilasi Dan Aplikasinya Pada Pembentukan Film. Jurnal Agrotek Ummat, 6(2), 100. https://doi.org/10.31764/agrotek.v6i2.1659

Nurliani, L., Dwiratna, S., & Prawiranegara, B. M. P. (2019). Analisis Penjadwalan Irigasi pada Budidaya Tanaman Talas Pratama (Colocasia esculenta (L). Schott var. Pratama) Menggunakan CROPWAT 8.0. Jurnal Teknotan, 13(2), 47. https://doi.org/10.24198/jt.vol13n2.3

Octavia, M., Syukri, Y., & Firdaus, F. (2019). Pengembangan Eksipien Sediaan Tablet Dari Pati Singkong Termodifikasi Secara Fisikokimia Untuk Peningkatan Sifat Farmasetikanya. Medical Sains 3(2), 119–130.

Puspadina, V., Budi Legowo, D., Fitriany, E., Priyoherianto, A., & Damayanti, W. (2021). Effect Of Variation Of Lubricant Concentration (Magnesium Stearate) On The Physical Quality Of Metoclopramid Hcl Tablets With Direct Printing Method. Indonesian Journal of Pharmaceutical Education, 1(2), 67–75. https://doi.org/10.37311/ijpe.v1i2.10567

Siregar CJ dan Wikarsa S. (2010). Teknologi Farmasi Sediaan Tablet Dasar-Dasar Praktis. Buku Kedokteran EGC.

Sirisha, V. N. L., Sruthi, B., & Eswaraiah, M. C. (2012). Preparation and in-vitro evaluation of liquid solid compacts of glibenclamide. International Research Journal of Pharmacy, 3(10), 111–114.

Yassir, M., & Asnah, A. (2019). Pemanfaatan Jenis Tumbuhan Obat Tradisional Di Desa Batu Hamparan Kabupaten Aceh Tenggara. BIOTIK: Jurnal Ilmiah Biologi Teknologi Dan Kependidikan, 6(1), 17. https://doi.org/10.22373/biotik.v6i1.4039

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Published

2024-03-13

How to Cite

Desy Nawangsari, Rani Prabandari, & Dina Febrina. (2024). Characterization of Pregelatinized, Pentanol and Acetylated Modified Primary Starch. Viva Medika: Jurnal Kesehatan, Kebidanan Dan Keperawatan, 17(1), 1–8. https://doi.org/10.35960/vm.v17i1.1354

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