Pengaruh Bahan Pengisi Terhadap Massa Cetak Tablet Vitamin C

Authors

  • Desy Nawangsari

DOI:

https://doi.org/10.35960/vm.v11i02.464

Keywords:

Avicel® PH, Vitamin C, Granul

Abstract

Avicel® PH is branded name from microcrystalline cellulose that is generally used in pharmaceutical preparations. Avicel® PH are being used as filler or binder in dosage formulas in tablets especially for direct compression because having a good flowing rate and a good compressibility. This study aims to compare the influence of the use Avicel® PH 101 and Avicel® PH 102 as a filler on of preparations a tablet of ascorbic acid. A method of the research was conducted by making granule of ascorbic acid tablet with the variation filler, then the granule was evaluate in .The results showed Avicel® PH 102 as a filler produce granule which better seen from the flowability, static angle of repose, carr’s index and hausner ratio .

 

References

Allison dan Laurent (2014): The Effect of Moisture on the Flowability of Pharmaceutical Excipients. AAPS PharmaSciTech. doi: 10.1208/s12249-013-0036-0.
Azubuike CP dan Okhamafe AO (2012): Physicochemical, spectroscopic, and thermal properties of microcrystalline cellulose derivied from corn crobs. Int Recycling of Org Waste Agric. 1:1-9. doi:10.1186/2251-7715-1-9.
Gohel, M. C. 2005. A Review of Co- processed Directly Compressible Excipients. J. Pharm Sci, Vol 8, no. 1: 76-93.
Lachman L., Lieberman, H.A., Kanig, J.L. (2008), The Theory and Practice of Industrial Pharmacy, 643-705, terjemahan Siti Suyatmi, Edisi ke-3, Jilid II, Universitas Indonesia Press, Jakarta.

Landín, M., P. González, Souto, Concheiro, Gómez-Amoza dan R. Martínez-Pacheco (2008): Comparison of two Varieties of Microcrystalline Cellulose as Filler-Binders II. Hydrochlorothiazide Tablets. Journal Drug Development and Industrial Pharmacy. Volume 19, 1993 - Issue 10
Ohwoavworhua, F.O., Adelakun, T.A., and Kunle, O. O., 2007, A Comparative Evaluation of the Flow and Compaction Characteristics of á-Cellulose obtained from Waste Paper, Trop J Pharm Res, March, 6 (1), 645-651.
Rowe RC, Sheskey PJ, dan Quinn ME. (2009): Handbook of Pharmaceutical Excipient, 6th Edition. USA: American Pharmacist Association.
Siregar, C.J.P. dan Wikarsa, S. (2010): Teknologi Farmasi Sediaan Tablet: Dasar-Dasar Praktis, Jakarta: EGC, Halaman 13-42.

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Published

2019-06-13

How to Cite

Nawangsari, D. (2019). Pengaruh Bahan Pengisi Terhadap Massa Cetak Tablet Vitamin C. Viva Medika: Jurnal Kesehatan, Kebidanan Dan Keperawatan, 12(02), 37–42. https://doi.org/10.35960/vm.v11i02.464