Activity Test of 96% Ethanol Extract of Water Guava Leaf (Syzygium aqueum) on LDL and HDL Values with Propylthiouracil Induction in Rats
DOI:
https://doi.org/10.35960/vm.v17i2.1472Keywords:
HDL, hyperlipidemia, LDL, Simvastatin, Syzygium aqueumAbstract
One of the plants that can be thought to have antihyperlipidemic potential is water guava leaves (Syzygium aqueum) because they contain chemical compounds, one of which is flavonoids. The aim of this research is to determine the activity of 96% ethanol extract of water guava leaves (EEDJA) as an antihyperlipidemic agent. Male Wistar rats were induced using propylthiouracil (PTU) for 2 weeks (14 days). Hyperlipidemic mice were divided into 5 test groups, CMC-Na group, simvastatin group, EEDJA group (100, 200 and 400) mg/BW. The solution was given to mice routinely once a day for 2 weeks (14 days) orally. The results of the study showed that there were differences before and after administration of EEDJA (100, 200 and 400) mg/BW in LDL and HDL levels with a significance value of 0.000 (<0.005). The conclusion from this study is that EEDJA has potential as an antihyperlipidemic agent in male white Wistar rats
References
Anggrawati, P.S., Ramadhania, Z.M., 2016. Review artikel: Kandungan senyawa kimia dan bioaktivitas dari jambu air (Syzygium aqueum burn. f. alston). Farmaka 14, 331–44.
Anief, M., 1999. Ilmu Meracik Obat. Gadjah Mada University Press, Yogyakarta.
Depkes, RI., 2008. Informatorium Obat Nasional Indonesia. Jkt. Badan Pengawas Obat Dan Makanan Jkt.
Eddouks, M., Lemhadri, A., Michel, J.-B., 2005. Hypolipidemic activity of aqueous extract of Capparis spinosa L. in normal and diabetic rats. J. Ethnopharmacol. 98, 345–350.
Endarini, L.H., 2016. Farmakognosi dan fitokimia. Jkt. Pusdik SDM Kesehat. 215.
Harini, M., Astirin, O.P., 2009. Kadar kolesterol darah tikus putih (Rattus norvegicus) hiperkolesterolemik setelah perlakuan VCO. Asian J. Trop. Biotechnol. 6, 53–58.
Hartono, F., Mukono, I.S., Rochmanti, M., 2020. Effects of golden sea cucumber (Stichopus hermanii) ethanol extracts on cholesterol levels of hypercholesterolemic rats. Indian J. Public Health Res. Dev. 11, 650–654.
Hasimun, P., Sukandar, E., Adnyana, I., Tjahjono, D., 2011. A simple method for screening antihyperlipidemic agents.
Mulyana, L., 2016. Uji Aktivitas Ekstrak Etanol Daun Jambu Bol (Syzygium malaccense L. Merr & Perry) Sebagai Antikolesterol Menggunakan Tikus Jantan. Universitas Sumatera Utara, Medan.
Murray, R., Granner, D., Rodwell, V., 2009. Biokimia Harper, Edisi ke-27. CV ECG Jkt.
Nofianti, T., Windiarti, D., Prasetyo, Y., 2015. Uji aktivitas ekstrak etanol krop kubis putih (Brassica oleracea L. var. capitata) terhadap kadar kolesterol total dan trigliserida serum darah tikus putih jantan galur Wistar. J. Kesehat. Bakti Tunas Husada J. Ilmu-Ilmu Keperawatan Anal. Kesehat. Dan Farm. 14, 74–83.
Noviani, M., Slamet, S., Wirasti, W., Waznah, U., 2021. Uji Aktivitas Antikolesterol Ekstrak Etanol Daun Jambu Air (Syzygium aqueum (Burm. f.) Alston) SecaraIn Vitro, in: Prosiding Seminar Nasional Kesehatan. pp. 839–849.
Perkeni, 2021. Pedoman Pengelolaan Dislipedimia Di Indonesia 2021. Pb, Perkeni, Jakarta.
Prasetyo, M., Inoriah, E., 2013. Pengelolaan budidaya tanaman obat-obatan (bahan simplisia). Bengkulu Badan Pnb. Fak. Pertan. UNIB 2.
Ratulangi, L.C., Wowor, P., Mambo, C., 2016. Uji efek perasan daging buah labu kuning (Cucurbita moschata D.) terhadap kadar kolesterol total darah tikus wistar (Rattus norvegicus). eBiomedik 4.
Rusdi, M., Mukhriani, M., Paramitha, A.T., 2018. Uji Penurunan Kolesterol Pada Mencit (Mus musculus) Secara In-Vivo Menggunakan Ekstrak Etanol Akar Parang Romang (Boehmeria virgata (Forst.) Guill). J. Farm. UIN Alauddin Makassar 6, 39–46.
Telaumbanua, I.A., Kristiani, E.B.E., 2022. Kadar Klorofil, Karotenoid, Dan Aktivitas Antioksidan Ekstrak Etanol Daun dari Dua Jenis Benalu Pada Tanaman Jambu Air (Syzygium aqueum), in: Prosiding Seminar Nasional MIPA UNIPA. pp. 55–61.
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