The Use of a Multi-Drug Therapy (MDT) Monitoring Calendar as a Medium to Support Medication Adherence in Leprosy Patients

Authors

  • Marianti Agustina Gudipun Poltekkes Kemenkes Kupang
  • Yoany Maria Vianney Bita Aty Poltekkes Kemenkes Kupang
  • Maria Selestina Sekunda Poltekkes Kemenkes Kupang
  • Aries Wawomeo Poltekkes Kemenkes Kupang
  • Florentianus Tat Poltekkes Kemenkes Kupang
  • Aben B.Y. Romana Poltekkes Kemenkes Kupang

DOI:

https://doi.org/10.35960/vm.v19i1.2117

Keywords:

Calender, Leprosy, Compliance, Multi-Drug Therapy, Medication Adherence

Abstract

Background: Treatment of leprosy with Multi-Drug Therapy (MDT) requires a relatively long duration, depending on the type of leprosy. The extended treatment period often leads to patient fatigue, which may reduce medication adherence and increase the risk of treatment discontinuation. This situation can hinder therapeutic success and elevate the risk of disease transmission and disability. Therefore, simple and practical strategies are needed to support patients in maintaining adherence throughout the treatment period. One potential strategy is the use of an MDT monitoring calendar as a reminder and monitoring tool. This study aimed to determine the effect of the MDT monitoring calendar on medication adherence among leprosy patients in Ende Regency. Methods: This quantitative study employed a pre-experimental one-group pre-test–post-test design. Total sampling was used, involving 16 respondents. Data were analyzed using the Wilcoxon Signed-Rank Test. Results: All respondents demonstrated an increase in medication adherence after the implementation of the Multi-Drug Therapy (MDT) monitoring calendar, with no observed decrease in adherence. The Wilcoxon Signed-Rank Test indicated statistically significant results (Z = −3.532; p < 0.05), confirming the effect of the MDT monitoring calendar on medication adherence among leprosy patients in Ende Regency. Conclusion: The implementation of the Multi-Drug Therapy (MDT) monitoring calendar significantly improved medication adherence among leprosy patients. The MDT monitoring calendar can serve as an effective and easily implementable health promotion tool to support treatment success. Health service facilities are encouraged to integrate the MDT monitoring calendar into the leprosy control program in Ende Regency

References

Ahmad, I., Ishak, S. N., & B. Toduho, N. (2023). Analysis of Medication Compliance in Leprosy Patients in the Working Area of the Kalumata Health Center. Journal of Social Sciences and Humanities (JSSH), 3(1), 45–52. https://doi.org/10.52046/jssh.v3i1.1542

Arshed, M., Mahmud, A. B., Minhat, H. S., Ying, L. P., & Umer, M. F. (2023). Effectiveness of mHealth Interventions in Medication Adherence among Patients with Cardiovascular Diseases: A Systematic Review. In Diseases (Vol. 11, Issue 1). MDPI. https://doi.org/10.3390/diseases11010041

Baek, J., Kim, K. H., & Choi, J. W. (2022). Determinants of adherence to personal preventive behaviours based on the health belief model: a cross-sectional study in South Korea during the initial stage of the COVID-19 pandemic. BMC Public Health, 22(1). https://doi.org/10.1186/s12889-022-13355-x

Ciziceno, M., Bertolazzi, A., & Quaglia, V. (2025). Examining cervical cancer screening adherence: how does healthism influence participation? BMC Public Health, 25(1). https://doi.org/10.1186/s12889-025-24631-x

Duwi Saputra, D., & Dhiah Anggraeni, A. (2025). The Effectiveness of Calendar Media on Increasing Adherence to The Consumption of Blood Supplement Tablets In Adolescent Girls as An Effort to Prevent Anemia. 7(2). http://jurnal.globalhealthsciencegroup.com/index.php/JPPP

Isturini, I. A. (2025). Leprosy Bulletin. https://sasakawaleprosyinitiative.org/latest-

Ministry of Health. (2018). Leprosy Control. Regulation of the Minister of Health of the Republic of Indonesia Number 4 of 2018, 151(2), 10–17.

Ministry of Health of the Republic of Indonesia. (2024). Indonesia's Health Profile 2024. https://kemkes.go.id/id/profil-kesehatan-indonesia-2024

Ministry of Health of the Republic of Indonesia. (2019). National Guidelines for Leprosy Management Medical Services. https://kemkes.go.id/id/pnpk-2019---tata-laksana-kusta

Lutfian, L., Wardika, I. J., Mukminin, M. A., Zamroni, A. H., Rizanti, A. P., Chandra, I. N., Widyaningtyas, R., Maressa, A., & Maulana, S. (2025). Effectiveness of health education in improving treatment adherence among patients with chronic communicable diseases: A systematic review and meta-analysis. In Tropical Medicine and International Health (Vol. 30, Issue 7, pp. 598–612). John Wiley and Sons Inc. https://doi.org/10.1111/tmi.14133

Patel, S., Huang, M., & Miliara, S. (2025). Understanding Treatment Adherence in Chronic Diseases: Challenges, Consequences, and Strategies for Improvement. In Journal of Clinical Medicine (Vol. 14, Issue 17). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/jcm14176034

Pepito, V. C. F., Amit, A. M. L., Samontina, R. E. D., Abdon, S. J. A., Fuentes, D. N. L., & Saniel, O. P. (2021). Patterns and determinants of treatment completion and default among newly diagnosed multibacillary leprosy patients: A retrospective cohort study. Heliyon, 7(6). https://doi.org/10.1016/j.heliyon.2021.e07279

Pepito, V. C. F., Loreche, A. M., Samontina, R. E. D., Abdon, S. J. A., Fuentes, D. N. L., & Saniel, O. P. (2023). Factors affecting treatment adherence among leprosy patients: Perceptions of healthcare providers. Heliyon, 9(7). https://doi.org/10.1016/j.heliyon.2023.e17975

Pratiwi, S. I., Mukarroma, N., & Wulandari, Y. (2018). The Effect of Health Education with Calendar Media on the Level of Medication Compliance of Morbus Hansen Patients in North Surabaya. APKMM Proceedings, April, 71–76.

Puspitasari, A. W., Andrajati, R., & Bahtiar, A. (2012). Analysis of the Effectiveness of Drug Booklets on the Compliance Level of Type 2 Diabetes Mellitus Patients. Journal of Management and Pharmacy Practice, 2(4), 195–202.

Qhumairah, A., Hamzah, W., & Haeruddin. (2024). Factors Related to Medication Compliance of Pulmonary TB Patients at dr. Lapalaloi Maros Hospital. Window of Public Health Journal, 5(3), 440–451. https://doi.org/10.33096/woph.v5i3.1029

Sahiddin, M. (2021). The Relationship Between Family Support and Drinking Compliance in Leprosy Patients. 4(1). http://jurnalpoltekkesjayapura.com/index.php/jktp

Tolley, A., Hassan, R., Sanghera, R., Grewal, K., Kong, R., Sodhi, B., & Basu, S. (2023). Interventions to promote medication adherence for chronic diseases in India: a systematic review. In Frontiers in Public Health (Vol. 11). Frontiers Media SA. https://doi.org/10.3389/fpubh.2023.1194919

Wahyudi Agusstyawan, F., Eko, A. T., Shidiq, P., Curahdami Bondowoso Regency, P., Jadid, N., & Health Bondowoso Regency, D. (2020). Family Social Support with Medication Compliance for Lepers in Bondowoso Regency. Journal of Professional Nursing (JKP), 8.

WHO. (2024). Global leprosy (Hansen disease) update, 2023: Elimination of leprosy disease is possible – Time to act! https://www.who.int/data/gho/data/themes/topics/leprosy-hansens-disease

WHO. (2025a). Control of Neglected Tropical Diseases Learn more. https://www.who.int/teams/control-of-neglected-tropical-diseases/leprosy/

WHO. (2025b). Leprosy. https://www.who.int/news-room/fact-sheets/detail/leprosy

Yuan, F., Yang, Q., Zhang, X., Luo, J., Lin, J., Chen, Y., Huang, H., He, J., & Cheng, L. (2025). Antirheumatic Medication Calendar Significantly Improves Adherence in First-Time Methotrexate Users: A Prospective, Single-Blind, Randomized Controlled Trial. Patient Preference and Adherence , 19, 2003–2014. https://doi.org/10.2147/PPA.S527173

Yuwindry, I., & Ivana Kabuhung, E. (2021). JOURNAL OF PHARMACY SCIENCE AND PRACTICE I VOLUME 8 I NUMBER 1 I FEBRUARI 2021. 8(1). https://www.dovepress.com/antirheumatic-medication-calendar-significantly-improves-adherence-in--peer-reviewed-fulltext-article-PPA

Zhang, J., Hu, J., Zheng, Y., & Dai, T. (2025). Factors affecting medication adherence in patients with chronic diseases: A systematic literature review. In Chinese General Practice Journal (Vol. 2, Issue 3). KeAi Communications Co. https://doi.org/10.1016/j.cgpj.2025.100072

Downloads

Published

2026-03-02

How to Cite

Marianti Agustina Gudipun, Yoany Maria Vianney Bita Aty, Maria Selestina Sekunda, Aries Wawomeo, Florentianus Tat, & Aben B.Y. Romana. (2026). The Use of a Multi-Drug Therapy (MDT) Monitoring Calendar as a Medium to Support Medication Adherence in Leprosy Patients. Viva Medika: Jurnal Kesehatan, Kebidanan Dan Keperawatan, 19(1), 9–18. https://doi.org/10.35960/vm.v19i1.2117

Issue

Section

Articles